{
  "schema_version": 1,
  "question_count": 6,
  "questions": [
    {
      "id": "cessation_nicotine_ecig_vs_nrt",
      "title": "Nicotine e-cigarettes for sustained smoking cessation",
      "population": "Adults who smoke and are attempting to quit",
      "comparators": [
        "nicotine replacement therapy",
        "non-nicotine e-cigarettes",
        "behavioural support or no support"
      ],
      "primary_outcomes": [
        "sustained abstinence at 6 months or longer",
        "serious adverse events"
      ],
      "preferred_designs": [
        "systematic_review_or_meta_analysis",
        "randomised_controlled_trial"
      ],
      "protocol_status": "question_framework_defined",
      "candidate_cards": 64,
      "result_bearing_candidate_cards": 58,
      "excluded_non_result_cards": 6,
      "excluded_non_result_design_counts": {
        "study_protocol": 6
      },
      "design_counts": {
        "cross_sectional": 3,
        "non_randomised_intervention": 1,
        "randomised_controlled_trial": 25,
        "study_protocol": 6,
        "systematic_review_or_meta_analysis": 5,
        "unknown": 24
      },
      "integrity_status_counts": {
        "unknown": 64
      },
      "effect_estimate_ready_cards": 0,
      "synthesis_status": "awaiting_structured_outcome_extraction_and_review",
      "notice": "Candidate count is a navigation/triage measure, not an effect estimate or certainty assessment. Protocols and post-publication notices are separately counted and excluded from result-bearing synthesis. Quantitative readiness also requires human review and a non-retracted integrity state."
    },
    {
      "id": "respiratory_health",
      "title": "Respiratory health outcomes associated with vaping",
      "population": null,
      "comparators": [
        "never use",
        "continued smoking",
        "former smoking without vaping",
        "dual use"
      ],
      "primary_outcomes": [
        "diagnosed respiratory disease",
        "symptoms",
        "lung function",
        "exacerbations"
      ],
      "preferred_designs": [],
      "protocol_status": "question_framework_defined",
      "candidate_cards": 99,
      "result_bearing_candidate_cards": 95,
      "excluded_non_result_cards": 4,
      "excluded_non_result_design_counts": {
        "post_publication_notice": 2,
        "study_protocol": 2
      },
      "design_counts": {
        "animal_study": 4,
        "case_report": 6,
        "commentary_or_editorial": 7,
        "in_vitro": 1,
        "non_randomised_intervention": 1,
        "post_publication_notice": 2,
        "qualitative_study": 1,
        "randomised_controlled_trial": 11,
        "study_protocol": 2,
        "systematic_review_or_meta_analysis": 1,
        "unknown": 63
      },
      "integrity_status_counts": {
        "unknown": 99
      },
      "effect_estimate_ready_cards": 0,
      "synthesis_status": "awaiting_structured_outcome_extraction_and_review",
      "notice": "Candidate count is a navigation/triage measure, not an effect estimate or certainty assessment. Protocols and post-publication notices are separately counted and excluded from result-bearing synthesis. Quantitative readiness also requires human review and a non-retracted integrity state."
    },
    {
      "id": "cardiovascular_health",
      "title": "Cardiovascular outcomes associated with vaping",
      "population": null,
      "comparators": [
        "never use",
        "continued smoking",
        "former smoking without vaping",
        "dual use"
      ],
      "primary_outcomes": [
        "cardiovascular disease",
        "events",
        "blood pressure",
        "vascular and cardiac biomarkers"
      ],
      "preferred_designs": [],
      "protocol_status": "question_framework_defined",
      "candidate_cards": 45,
      "result_bearing_candidate_cards": 44,
      "excluded_non_result_cards": 1,
      "excluded_non_result_design_counts": {
        "study_protocol": 1
      },
      "design_counts": {
        "animal_study": 1,
        "case_control": 1,
        "case_report": 1,
        "commentary_or_editorial": 1,
        "cross_sectional": 1,
        "in_vitro": 1,
        "non_randomised_intervention": 1,
        "randomised_controlled_trial": 6,
        "study_protocol": 1,
        "systematic_review_or_meta_analysis": 1,
        "unknown": 30
      },
      "integrity_status_counts": {
        "unknown": 45
      },
      "effect_estimate_ready_cards": 0,
      "synthesis_status": "awaiting_structured_outcome_extraction_and_review",
      "notice": "Candidate count is a navigation/triage measure, not an effect estimate or certainty assessment. Protocols and post-publication notices are separately counted and excluded from result-bearing synthesis. Quantitative readiness also requires human review and a non-retracted integrity state."
    },
    {
      "id": "youth_use",
      "title": "Vaping among children and young people",
      "population": null,
      "comparators": [
        "never smokers",
        "ever smokers",
        "current smokers",
        "age and socioeconomic groups"
      ],
      "primary_outcomes": [
        "ever use",
        "current use",
        "regular use",
        "nicotine use",
        "subsequent smoking"
      ],
      "preferred_designs": [],
      "protocol_status": "question_framework_defined",
      "candidate_cards": 183,
      "result_bearing_candidate_cards": 172,
      "excluded_non_result_cards": 11,
      "excluded_non_result_design_counts": {
        "post_publication_notice": 3,
        "study_protocol": 8
      },
      "design_counts": {
        "case_report": 1,
        "commentary_or_editorial": 8,
        "cross_sectional": 18,
        "post_publication_notice": 3,
        "qualitative_study": 7,
        "randomised_controlled_trial": 13,
        "study_protocol": 8,
        "systematic_review_or_meta_analysis": 6,
        "unknown": 119
      },
      "integrity_status_counts": {
        "unknown": 183
      },
      "effect_estimate_ready_cards": 0,
      "synthesis_status": "awaiting_structured_outcome_extraction_and_review",
      "notice": "Candidate count is a navigation/triage measure, not an effect estimate or certainty assessment. Protocols and post-publication notices are separately counted and excluded from result-bearing synthesis. Quantitative readiness also requires human review and a non-retracted integrity state."
    },
    {
      "id": "secondhand_exposure",
      "title": "Second-hand vaping aerosol exposure",
      "population": null,
      "comparators": [
        "no vaping exposure",
        "cigarette smoke exposure",
        "ambient background"
      ],
      "primary_outcomes": [
        "particle number and size",
        "nicotine",
        "carbonyls and VOCs",
        "biomarkers",
        "symptoms"
      ],
      "preferred_designs": [],
      "protocol_status": "question_framework_defined",
      "candidate_cards": 18,
      "result_bearing_candidate_cards": 18,
      "excluded_non_result_cards": 0,
      "excluded_non_result_design_counts": {},
      "design_counts": {
        "animal_study": 1,
        "cross_sectional": 1,
        "non_randomised_intervention": 1,
        "randomised_controlled_trial": 4,
        "systematic_review_or_meta_analysis": 1,
        "unknown": 10
      },
      "integrity_status_counts": {
        "unknown": 18
      },
      "effect_estimate_ready_cards": 0,
      "synthesis_status": "awaiting_structured_outcome_extraction_and_review",
      "notice": "Candidate count is a navigation/triage measure, not an effect estimate or certainty assessment. Protocols and post-publication notices are separately counted and excluded from result-bearing synthesis. Quantitative readiness also requires human review and a non-retracted integrity state."
    },
    {
      "id": "thirdhand_residue",
      "title": "Third-hand vaping residues and exposure",
      "population": null,
      "comparators": [
        "unexposed surfaces or environments",
        "tobacco smoke residues"
      ],
      "primary_outcomes": [
        "surface nicotine",
        "chemical transformation",
        "transfer or biomarker evidence"
      ],
      "preferred_designs": [],
      "protocol_status": "question_framework_defined",
      "candidate_cards": 2,
      "result_bearing_candidate_cards": 2,
      "excluded_non_result_cards": 0,
      "excluded_non_result_design_counts": {},
      "design_counts": {
        "unknown": 2
      },
      "integrity_status_counts": {
        "unknown": 2
      },
      "effect_estimate_ready_cards": 0,
      "synthesis_status": "awaiting_structured_outcome_extraction_and_review",
      "notice": "Candidate count is a navigation/triage measure, not an effect estimate or certainty assessment. Protocols and post-publication notices are separately counted and excluded from result-bearing synthesis. Quantitative readiness also requires human review and a non-retracted integrity state."
    }
  ],
  "governance": "No pooled effect or causal conclusion is produced until comparator, outcome, effect-estimate and risk-of-bias fields have been source-grounded and reviewed."
}