{ "schema_version": 4, "scope": "vaping_specific_evidence_inventory_and_synthesis_readiness", "literature": { "source_records": { "pubmed_eutils": 100, "europe_pmc": 1000, "crossref": 100 }, "input_records": 1200, "canonical_records": 910, "canonical_records_before_quality_gate": 1123, "quarantined_records": 1416, "quarantine_reason_counts": { "cannabis_vaping_without_nicotine_or_ecig_context": 14, "no_explicit_vaping_ecig_ends_or_nicotine_pouch_anchor": 1195, "not_direct_vaping_nicotine_evidence": 1209, "pre_modern_ecigarette_publication_year": 105, "retraction_record_not_primary_evidence": 2, "secondary_only_title_not_vaping_specific": 100 }, "duplicates_collapsed": 77, "source_overlap": { "clinicaltrials_pubmed_recovery": 1097, "europe_pmc": 922, "europe_pmc+pubmed_eutils": 75, "pubmed_eutils": 25 }, "publication_year_counts": { "unknown": 6, "2027": 2, "2026": 556, "2025": 31, "2024": 24, "2023": 23, "2022": 19, "2021": 31, "2020": 50, "2019": 37, "2018": 17, "2017": 17, "2016": 27, "2015": 21, "2014": 26, "2013": 14, "2012": 5, "2011": 3, "2010": 1 }, "publication_type_counts": { "Journal Article": 824, "research-article": 174, "Research Support, Non-U.S. Gov't": 117, "Research Support, N.I.H., Extramural": 109, "Randomized Controlled Trial": 102, "Review": 75, "Preprint": 42, "review-article": 28, "Research Support, U.S. Gov't, P.H.S.": 23, "Clinical Trial Protocol": 21, "Letter": 20, "Comparative Study": 20, "Systematic Review": 17, "Case Reports": 13, "Editorial": 12, "Multicenter Study": 11, "Observational Study": 9, "Meta-Analysis": 9, "Clinical Trial": 9, "case-report": 7, "brief-report": 7, "Comment": 6, "Research Support, U.S. Gov't, Non-P.H.S.": 6, "Published Erratum": 6, "Validation Study": 5, "systematic-review": 4, "Pragmatic Clinical Trial": 4, "Abstract": 4, "English Abstract": 3, "letter": 3, "News": 3, "discussion": 3, "correction": 3, "Controlled Clinical Trial": 3, "article-commentary": 2, "Practice Guideline": 2, "Clinical Trial, Phase II": 2, "Scoping Review": 1, "methods-article": 1, "editorial": 1, "other": 1, "in-brief": 1, "IM": 1, "Clinical Trial, Phase IV": 1, "Equivalence Trial": 1, "Lecture": 1, "Research Support, N.I.H., Intramural": 1, "Evaluation Study": 1, "Historical Article": 1, "Clinical Conference": 1 }, "topic_counts": { "aerosol_chemistry": 11, "cardiovascular": 113, "cessation": 151, "exposure_biomarkers": 31, "indoor_air": 5, "respiratory": 204, "secondhand_exposure": 7, "thirdhand_residue": 2, "ultrafine_particles": 3, "youth": 387 }, "topic_policy": "Auditable title/journal keyword tags are navigation aids only and are not evidence-strength or effect classifications.", "relevance_policy": "Public evidence-card promotion requires an explicit vaping, e-cigarette, ENDS, e-liquid or nicotine-pouch anchor. Broad smoking/tobacco/health records and cannabis-only vaping records remain auditable in quarantine rather than being discarded.", "trial_publication_recovery": { "source": "NCBI PubMed ESummary exact PMID retrieval from ClinicalTrials.gov references", "recovered_source_records": 1204, "accepted_before_direct_relevance_gate": 1098, "quality_quarantined": 106, "policy": "Identifier recovery expands coverage only. Recovered publications still pass the ordinary quality and direct-vaping relevance gates and registry linkage does not establish outcome reporting completeness or reliability." } }, "evidence_cards": { "card_count": 910, "study_design_counts": { "animal_study": 7, "case_control": 1, "case_report": 15, "case_series": 1, "commentary_or_editorial": 36, "cross_sectional": 51, "in_vitro": 4, "modelling_study": 1, "non_randomised_intervention": 14, "post_publication_notice": 6, "prospective_cohort": 2, "qualitative_study": 16, "randomised_controlled_trial": 108, "study_protocol": 35, "systematic_review_or_meta_analysis": 36, "unknown": 577 }, "integrity_status_counts": { "unknown": 910 }, "extraction_policy": "Metadata classification is automated and provisional. Integrity status remains unknown unless a collected integrity source or explicit bibliographic signal supplies a post-publication state. Effect estimates, comparators, confounding, funding and risk-of-bias fields require source-grounded extraction and review before synthesis." }, "review_readiness": { "schema_version": 1, "generated_at": "2026-10-06T04:58:34.321347+00:00", "record_count": 910, "study_design_counts": { "unknown": 577, "animal_study": 7, "cross_sectional": 51, "case_report": 15, "commentary_or_editorial": 36, "qualitative_study": 16, "randomised_controlled_trial": 108, "prospective_cohort": 2, "in_vitro": 4, "systematic_review_or_meta_analysis": 36, "study_protocol": 35, "modelling_study": 1, "case_control": 1, "post_publication_notice": 6, "non_randomised_intervention": 14, "case_series": 1 }, "integrity_status_counts": { "unknown": 910 }, "human_review_status_counts": { "not_reviewed": 910 }, "synthesis_readiness_counts": { "metadata_classified_requires_outcome_extraction": 910 }, "unknown_study_design": { "count": 577, "percent": 63.41 }, "unknown_integrity_status": { "count": 910, "percent": 100.0 }, "reviewed_record_count": 0, "conclusion_sensitive_ready_record_count": 0, "conclusion_field_presence": { "population": { "count": 0, "percent": 0.0 }, "smoking_history": { "count": 0, "percent": 0.0 }, "dual_use": { "count": 0, "percent": 0.0 }, "intervention_exposure": { "count": 0, "percent": 0.0 }, "comparator": { "count": 0, "percent": 0.0 }, "outcomes": { "count": 0, "percent": 0.0 }, "effect_estimates": { "count": 0, "percent": 0.0 }, "funding": { "count": 0, "percent": 0.0 }, "conflicts_of_interest": { "count": 0, "percent": 0.0 }, "risk_of_bias": { "count": 0, "percent": 0.0 } }, "phase_gates": { "external_method_review_candidate": true, "conclusion_sensitive_synthesis_has_any_reviewed_ready_records": false, "all_study_designs_resolved": false, "all_integrity_states_resolved": false }, "interpretation": "This is an operational readiness report, not an evidence-certainty rating. No threshold in this report establishes a health conclusion." }, "synthesis": { "question_count": 6, "questions": [ { "id": "cessation_nicotine_ecig_vs_nrt", "title": "Nicotine e-cigarettes for sustained smoking cessation", "candidate_cards": 64, "effect_estimate_ready_cards": 0, "synthesis_status": "awaiting_structured_outcome_extraction_and_review" }, { "id": "respiratory_health", "title": "Respiratory health outcomes associated with vaping", "candidate_cards": 99, "effect_estimate_ready_cards": 0, "synthesis_status": "awaiting_structured_outcome_extraction_and_review" }, { "id": "cardiovascular_health", "title": "Cardiovascular outcomes associated with vaping", "candidate_cards": 45, "effect_estimate_ready_cards": 0, "synthesis_status": "awaiting_structured_outcome_extraction_and_review" }, { "id": "youth_use", "title": "Vaping among children and young people", "candidate_cards": 183, "effect_estimate_ready_cards": 0, "synthesis_status": "awaiting_structured_outcome_extraction_and_review" }, { "id": "secondhand_exposure", "title": "Second-hand vaping aerosol exposure", "candidate_cards": 18, "effect_estimate_ready_cards": 0, "synthesis_status": "awaiting_structured_outcome_extraction_and_review" }, { "id": "thirdhand_residue", "title": "Third-hand vaping residues and exposure", "candidate_cards": 2, "effect_estimate_ready_cards": 0, "synthesis_status": "awaiting_structured_outcome_extraction_and_review" } ], "governance": "No pooled effect or causal conclusion is produced until comparator, outcome, effect-estimate and risk-of-bias fields have been source-grounded and reviewed." }, "clinical_trials": { "record_count": 842, "total_matches": 842, "status_counts": { "ACTIVE_NOT_RECRUITING": 29, "COMPLETED": 499, "ENROLLING_BY_INVITATION": 13, "NOT_YET_RECRUITING": 54, "RECRUITING": 133, "SUSPENDED": 2, "TERMINATED": 30, "UNKNOWN": 56, "WITHDRAWN": 26 }, "study_type_counts": { "INTERVENTIONAL": 702, "OBSERVATIONAL": 140 }, "trials_with_results": 191, "trials_with_primary_outcomes": 842, "trials_with_result_outcome_measures": 191, "publication_pmids_linked": 1211, "trials_with_matched_evidence_cards": 172, "unique_pmids_matched_to_evidence_cards": 365, "unique_referenced_pmids": 1211, "unmatched_referenced_pmids": 846, "reference_type_summary": { "BACKGROUND": { "unique_pmids": 935, "matched_pmids": 212, "unmatched_pmids": 723 }, "DERIVED": { "unique_pmids": 249, "matched_pmids": 142, "unmatched_pmids": 107 }, "RESULT": { "unique_pmids": 40, "matched_pmids": 22, "unmatched_pmids": 18 } }, "result_reference_pmids": 40, "result_pmids_matched_to_evidence_cards": 22, "unmatched_result_pmids": 18, "linkage_interpretation": "RESULT references are the appropriate headline publication-linkage metric. DERIVED references and BACKGROUND bibliography are retained for audit but are not counted as missing trial-result publications." }, "official_prevalence_resources": [ { "source_id": "ons", "resource_title": "xlsx (93.9 KB)", "page_url": "https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/healthandlifeexpectancies/datasets/ecigaretteuseinengland", "resource_url": "https://www.ons.gov.uk/file?uri=/peoplepopulationandcommunity/healthandsocialcare/healthandlifeexpectancies/datasets/ecigaretteuseinengland/2024/ecigaretteuseinengland2024.xlsx", "bytes": 96189, "sha256": "cd8d4162d16201b0ff573702a0f0910aee793b1ecf07c48b643fe7028d1d96b0", "interpretation_status": "resource_captured_for_statistical_parser" }, { "source_id": "nhs_england", "resource_title": "Smoking, drinking and drug use among young people, England, 2023: Part 4 data tables - Electronic cigarette use", "page_url": "https://digital.nhs.uk/data-and-information/publications/statistical/smoking-drinking-and-drug-use-among-young-people-in-england/2023/data-tables", "resource_url": "https://files.digital.nhs.uk/17/54B245/sdd_2023_tab4.xlsx", "bytes": 104683, "sha256": "3cae36aa0c061ebec91fec62a3c6aaa62431bd6408548991818e06a6110f3264", "interpretation_status": "resource_captured_for_statistical_parser" } ], "official_prevalence": { "ons": { "status": "parsed", "latest_year": 2024, "estimate_count": 1188, "latest_year_estimate_count": 108, "interpretation": "Official ONS survey estimates with 95% confidence limits. Survey/question changes in 2018 and 2020 affect parts of the time series; the accompanying ONS notes and change statements must be retained." }, "ohid_youth": { "status": "parsed", "record_count": 96, "indicators": [ "Have ever used e-cigarettes, 15 year olds", "Regular e-cigarette users, 15 year olds" ], "interpretation": "Official youth-vaping estimates from NHS England SDD and OHID are kept with survey/geography/demographic provenance. Percentages, unweighted bases and weighted bases must not be mixed across survey definitions or interpreted as causal health effects. NHS table schema changes fail closed for review." }, "nhs_youth": { "status": "parsed", "record_count": 423, "survey_year": 2023, "tables_structured": [ "4.2", "4.3", "4.4", "4.5", "4.6" ], "indicators": [ "Current e-cigarette user", "Current e-cigarettes users", "Ever used e-cigarettes", "Ex e-cigarette user", "Never used e-cigarettes", "Occasional e-cigarette user", "Regular e-cigarette user", "Tried using e-cigarettes" ], "release_check": { "discovery_status": "latest_release_check_unavailable", "freshness_status": "awaiting_scheduled_release", "expected_next_survey_year": 2025, "expected_publication_year": 2026, "expected_publication_window_end": "2026-11-30" }, "interpretation": "Official youth-vaping estimates from NHS England SDD and OHID are kept with survey/geography/demographic provenance. Percentages, unweighted bases and weighted bases must not be mixed across survey definitions or interpreted as causal health effects. NHS table schema changes fail closed for review." } }, "regulatory_context": { "milestone_count": 8, "reviewed_at": "2026-08-16", "notice": "This is a research timeline, not legal advice. Effective requirements must be checked against current legislation and official guidance." }, "environment_context": { "status": "optional_background_control_only", "interpretation": "General air-quality and satellite collectors are no longer part of the default vaping harvest. They may be enabled for a defined exposure study as background control data." }, "limitations": [ "Counts are not effect estimates and do not establish causation, safety, harm or certainty.", "Automated study-design classification is provisional until human review.", "Structured comparator, outcome, effect-estimate, risk-of-bias and funding fields are not yet complete enough for pooled quantitative synthesis.", "Recent-first literature surveillance plus identifier-based trial-publication recovery is not yet a complete historical systematic review; broader backfill remains a separate governed stage.", "Registry BACKGROUND references are not missing trial-result publications and are excluded from the headline RESULT-publication linkage gap.", "Official prevalence estimates must retain survey, geography, confidence-interval and comparability metadata." ] }